Content is reviewed and updated for general UK information accuracy. Last reviewed: March 2026.

Polynucleotides

Regenerative injectable using purified polynucleotide chains to support skin repair and quality.

What is Polynucleotides?

Polynucleotide treatments use purified DNA fragments — typically derived from salmon or trout — to stimulate the skin's natural repair and regeneration processes. Unlike dermal fillers, polynucleotides do not add volume. Instead, they work at a cellular level to support fibroblast activity, improve skin elasticity and hydration, and reduce the appearance of fine lines and textural irregularities. Treatment is delivered as a series of small injections into the skin, usually across 2–4 sessions spaced 2–4 weeks apart. Results develop gradually over several weeks as collagen and elastin production increases. Polynucleotides are a relatively recent addition to the UK aesthetic market but are growing rapidly in popularity, particularly among patients seeking regenerative skin-quality improvement without the volume changes associated with fillers.

Suitability

Polynucleotides may be suitable for patients looking to improve skin quality, hydration and elasticity — particularly those with early signs of ageing, crepey skin, sun damage or loss of skin firmness. They can be used on the face, neck, décolletage and hands. The treatment is often positioned as a 'next step' for patients who have tried skin boosters and want a more regenerative approach, or as a complement to treatments like Profhilo or microneedling. The practitioner should assess your skin at a clinical consultation and explain what results to realistically expect for your skin type and age.

Procedure-specific clinical focus

Polynucleotide protocols target skin regeneration through fibroblast stimulation and improved tissue hydration.

What a thorough consultation should cover

Consultations should assess skin quality, treatment goals, contraindications including autoimmune conditions, and agree a realistic course plan.

Who should avoid or delay treatment?

Patients who are pregnant or breastfeeding, those with active skin infections or inflammation in the treatment area, individuals with known allergies to the source material (salmon or trout DNA), patients with autoimmune conditions (discuss on a case-by-case basis), and those on immunosuppressive medication should discuss suitability carefully with their practitioner before proceeding. A practitioner who does not take a full medical history before treatment is a red flag.

Risks and side effects

Common short-term effects include redness, swelling, small bumps at injection points, mild bruising and tenderness — these typically resolve within 24–72 hours. Less common risks include infection (rare, when performed in a clinical setting with sterile technique), allergic reaction, and nodule formation. Serious complications are uncommon but should be discussed during the consent process. As with all injectable treatments, choosing a qualified practitioner in a regulated clinical environment significantly reduces risk.

Aftercare

Avoid touching, rubbing or massaging the treated area for at least 6 hours. Avoid intense exercise, saunas, steam rooms and direct sun exposure for 24–48 hours. Apply sunscreen (SPF 30+) daily. Avoid retinoids and active skincare (AHAs, BHAs, vitamin C serums) for 48 hours post-treatment. Attend any scheduled follow-up appointments. Report any unusual swelling, persistent redness or signs of infection to your practitioner promptly.

Choosing a qualified practitioner

Look for a GDC-registered dentist, GMC-registered doctor or NMC-registered nurse prescriber with specific training in polynucleotide injection techniques. Check their registration on the relevant public register. Ask about their experience with polynucleotides specifically, the product brand they use, and their protocol for managing adverse events. Save Face accreditation and CQC registration (in England) are additional trust markers. See our verification methodology page for how ClinicSpark checks each listed practice.

Realistic expectations

Polynucleotides work gradually. Most patients notice improvement in skin texture, hydration and firmness over 4–8 weeks after their initial course. The treatment does not produce the immediate volumising effect of fillers or the rapid smoothing of anti-wrinkle injections. Results are typically described as a natural improvement in skin quality rather than a dramatic change. Maintenance sessions are usually recommended every 6–12 months.

Cost factors

Polynucleotide treatment in the UK typically costs £200–£400 per session, with a course of 2–4 sessions running £400–£1,200. Prices vary by practitioner qualifications, product brand, geographic location and the number of sessions recommended. London and the South East are 15–25% above the national average. Course pricing is usually better value per session than individual appointments. Always ask what is included in the quoted price — consultation, product, aftercare and follow-up should all be covered.